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Publications

Prof. Haim Cohen
Prof. Haim Cohen

Prof. Haim Cohen

Aging and Metabolism

  1. Simon M., Van Meter M., Ablaeva J., Ke., Gonzalez R.S., Taguchi T., De Cecco M., Leonova K.I., Kogan V., Helfand S.L., Neretti N., Roichman A., Cohen H.Y., Meer M.V., Gladyshev V.N., Antoch M.P., Gudkov A.V., Sedivy J.M., Seluanov A. and Gorbunova V.  (2019) LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation. Cell Met. 29:871-85.

  2. Shekhidem H.D., Sharvit L., Leman E., Manov I., Roichman A., Holtze S., Huffman D.M, Cohen H.Y., Hildebrandt T.B, Shams I. and  Atzmon G. Telomeres and Longevity: A Cause or an Effect? (2019) Int. J. Mol. Sci. 20:3233.

  3. Naiman S., Huynh F.K., Gil R., Glick Y., Shahar Y., Touitou N., Nahum L., Avivi1 M.Y., Roichman A., Kanfi Y., Gertler A.A., Doniger T.,  Ilkayeva O.R., Abramovich I., Yaron O., Lerrer B., Gottlieb E., Harris R.A.,  Gerber D., Hirschey M.D. and Cohen H.Y.  SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARa (2019) Cell Rep.  29:4127-4143.

  4. Andrawus M., Sharvit L., Shekhidem H.A., Roichman A., Cohen H.Y. and Atzmon G. The Effects of Environmental Stressors on Candidate Aging Associated Genes. (2020) Exp Gerontol.  137:110952.

  5. Levy O., Amit G., Vaknin D., Snir T., Efroni S., Castaldi P., Liu Y., Cohen H.Y and Bashan A. (2020) Age-related loss of gene-to-gene transcriptional coordination among single cells. Nature Metabolism.  2(11):1305-1315.

  6. Roichman A., Elhanati S., Aon M.A., Abramovich I., di Francesco A., Shahar Y., Avivi M.Y., …, Kanfi Y., Lerrer B., Fernández-Marcos PJ., Serrano M., Gottlieb E., de Cabo R., & Cohen H.Y.  Restoration of energy homeostasis by SIRT6 extends healthy lifespan. (2021) Nature Communications.  12: (1)3208.

  7. Ben-Haim M.S.,  Pinto Y., Moshitch-Moshkovitz S.,  Hershkovitz V.,  Kol N., Diamant-Levi T., Michal Schnaider Beeri M., Amariglio N., Cohen H.Y*.  and  Rechavi G*.  (2021) N6,2′-O-dimethyladenosine (m6Am) Regulates High Fat Western Diet Induced Obesity. Nat. Communications. 2021 12(1):7185. *equal correspondence.

  8. Yeroslavsky G., Richman M., Gertler A., Cohen H.Y., Motiei M., Popovtzer R., Gottlieb H.G. and Rahimipour S. (2021) Polydopamine Nanoparticles Containing a Cisplatin Analog for Anticancer Treatment and Diagnostics . ACS Applied Nano Materials. 4(12): 14126-14135.

  9. Katz A, Gonen M, Shahar Y, Roichman A, Lerrer B and Cohen H.Y.  (2022) Hypothalamus-Muscle Parallel Induction of Metabolic Pathways Following Physical Exercise. Front Neurosci. 2022 Jul 19;16:897005. doi: 10.3389/fnins.2022.897005. eCollection 2022.  [IF 5] Rank A 8 citations.

  10. Andrawus M, Sharvit L, Touitou N, Lerrer B, Cohen H.Y, Atzmon G.  (2023) Copy number variation as a tool for implementing pregnancy as an aging model. Aging 15(16):7922-7932.

  11. Touitou N, Lerrer B and Cohen H.Y. (2023) It is a branched road to adipose tissue aging. Nat Aging. 2023 (8):911-912.

  12. Avivi M.Y., Touitou N., Rohana H., Lerrer B., Shav-Tal Y., Peretz A. and Cohen H.Y. (2024) Nucleic acid hybridization-based detection of pathogenic RNA using microscale thermophoresis. JBC 300(3):105676.

  13. Feldman-Trabelsi S., Touitou N., Nagar R., Schwartz Z., Michelson A., Shaki S., Avivi M.Y., Lerrer B., Snir S. and Cohen H.Y. (2025) mammalian longevity associated acetylome. Nat. Communications 16(1):3749.

  14. Cohen H.Y., Gorbunova V, Horvath S, Kennedy BK, Li W, de Magalhães JP, Seluanov A, Song M, Suzuki K. (2025) Perspectives on the essence and drivers of aging. Life Med. 2025 Feb 22;4(2):lnaf006. doi: 10.1093/lifemedi/lnaf006. eCollection 2025 Apr.

  15. Touitou N. Nahum L., Feldman-Trabelsi S., Avivi M.Y., Aon M., Naiman S., Rathaus M., Gertler., Roichman A., Berkman Dvir L., Bernier M., Banskota N., Beck L., Nagar R., Schwartz Z., Price N., Harel M., Lerrer B., Ishii I., Senderowitz  H., Moaddel R., Geiger T.,  de Cabo R., and Cohen H.Y. (2025) Sirt6 prevents the age-related decline of H2S through the control of one-carbon metabolism. PNAS 122 (46) e2514084122

Prof. Dr.  Björn Schumacher

Prof. Dr. Björn Schumacher

Aging and Genome Stability

Prof. Dr. Björn Schumacher

  1. Habermehl TL, Parkinson KC, Hubbard GB, Ikeno Y, Engelmeyer JI, Schumacher B, Mason JB. (2019) Extension of longevity and reduction of inflammation is ovarian-dependent, but germ cell-independent in post-reproductive female mice. Geroscience. 2019 Feb;41(1):25-38. doi: 10.1007/s11357-018-0049-4. Epub 2018 Dec 13.

  2. Jachimowicz RD, Beleggia F, Isensee J, Velpula BB, Goergens J, Bustos MA, Doll MA, Shenoy A, Checa-Rodriguez C, Wiederstein JL, Baranes-Bachar K, Bartenhagen C, Hertwig F, Teper N, Nishi T, Schmitt A, Distelmaier F, Lüdecke HJ, Albrecht B, Krüger M, Schumacher B, Geiger T, Hoon DSB, Huertas P, Fischer M, Hucho T, Peifer M, Ziv Y, Reinhardt HC, Wieczorek D, Shiloh Y. (2019) UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors. Cell. 2019 Jan 24;176(3):505-519.e22. doi: 10.1016/j.cell.2018.11.024. Epub 2019 Jan 3.

  3. Williams AB, Heider F, Messling JE, Rieckher M, Bloch W, Schumacher B. (2019) Restoration of Proteostasis in the Endoplasmic Reticulum Reverses an Inflammation-Like Response to Cytoplasmic DNA in Caenorhabditis elegans. Genetics. 2019 Aug;212(4):1259-1278. doi: 10.1534/genetics.119.302422. Epub 2019 Jun 27.

  4. Doll MA, Soltanmohammadi N, Schumacher B. (2019) ALG-2/AGO-Dependent mir-35 Family Regulates DNA Damage-Induced Apoptosis Through MPK-1/ERK MAPK Signaling Downstream of the Core Apoptotic Machinery in Caenorhabditis elegans. Genetics. 2019 Sep;213(1):173-194. doi: 10.1534/genetics.119.302458. Epub 2019 Jul 11.

  5. Ou HL, Kim CS, Uszkoreit S, Wickström SA, Schumacher B. (2019) Somatic Niche Cells Regulate the CEP-1/p53-Mediated DNA Damage Response in Primordial Germ Cells. Dev Cell. 2019 Jul 22;50(2):167-183.e8. doi: 10.1016/j.devcel.2019.06.012.

  6. Bayersdorf R, Schumacher B. (2019) Recent advances in understanding the mechanisms determining longevity. F1000Res. 2019 Aug 9;8:F1000 Faculty Rev-1403. doi: 10.12688/f1000research.19610.1. eCollection 2019.

  7. Rive C, Reina G, Wagle P, Treossi E, Palermo V, Bianco A, Delogu LG, Rieckher M, Schumacher B. (2019) Improved Biocompatibility of Amino-Functionalized Graphene Oxide in Caenorhabditis elegans. Small. 2019 Nov;15(45):e1902699. doi: 10.1002/smll.201902699. Epub 2019 Oct 1.

  8. da Silva PFL, Schumacher B. (2019) DNA damage responses in ageing. Open Biol. 2019 Nov 29;9(11):190168. doi: 10.1098/rsob.190168. Epub 2019 Nov 20.

  9. Schumacher B, Vijg J. (2019) Age is in the nucleus. Nat Metab. 2019 Oct;1(10):931-932. doi: 10.1038/s42255-019-0125-9.

  10. Lopes AFC, Bozek K, Herholz M, Trifunovic A, Rieckher M, Schumacher B. (2020) A C. elegans model for neurodegeneration in Cockayne syndrome. Nucleic Acids Res. 2020 Nov 4;48(19):10973-10985. doi: 10.1093/nar/gkaa795.

  11. Wang S, Meyer DH, Schumacher B. (2020) H3K4me2 regulates the recovery of protein biosynthesis and homeostasis following DNA damage. Nat Struct Mol Biol. 2020 Dec;27(12):1165-1177. doi: 10.1038/s41594-020-00513-1. Epub 2020 Oct 12.

  12. Gebel J, Tuppi M, Sänger N, Schumacher B, Dötsch V. (2020) DNA Damaged Induced Cell Death in Oocytes. Molecules. 2020 Dec 3;25(23):5714. doi: 10.3390/molecules25235714.

  13. Mkrtchyan GV, Abdelmohsen K, Andreux P, Bagdonaite I, Barzilai N, Brunak S, Cabreiro F, de Cabo R, Campisi J, Cuervo AM, Demaria M, Ewald CY, Fang EF, Faragher R, Ferrucci L, Freund A, Silva-García CG, Georgievskaya A, Gladyshev VN, Glass DJ, Gorbunova V, de Grey A, He WW, Hoeijmakers J, Hoffmann E, Horvath S, Houtkooper RH, Jensen MK, Jensen MB, Kane A, Kassem M, de Keizer P, Kennedy B, Karsenty G, Lamming DW, Lee KF, MacAulay N, Mamoshina P, Mellon J, Molenaars M, Moskalev A, Mund A, Niedernhofer L, Osborne B, Pak HH, Parkhitko A, Raimundo N, Rando TA, Rasmussen LJ, Reis C, Riedel CG, Franco-Romero A, Schumacher B, Sinclair DA, Suh Y, Taub PR, Toiber D, Treebak JT, Valenzano DR, Verdin E, Vijg J, Young S, Zhang L, Bakula D, Zhavoronkov A, Scheibye-Knudsen M. (2020) ARDD 2020: from aging mechanisms to interventions. Aging (Albany NY). 2020 Dec 30;12(24):24484-24503. doi: 10.18632/aging.202454. Epub 2020 Dec 30.

  14. da Silva PFL, Schumacher B. (2021) Principles of the Molecular and Cellular Mechanisms of Aging. J Invest Dermatol. 2021 Apr;141(4S):951-960. doi: 10.1016/j.jid.2020.11.018. Epub 2021 Jan 29.

  15. Meyer DH, Schumacher B. (2021) BiT age: A transcriptome-based aging clock near the theoretical limit of accuracy. Aging Cell. 2021 Mar;20(3):e13320. doi: 10.1111/acel.13320. Epub 2021 Mar 3.

  16. Schumacher B, Krieg TM. (2021) The Aging Skin: From Basic Mechanisms to Clinical Applications. J Invest Dermatol. 2021 Apr;141(4S):949-950. doi: 10.1016/j.jid.2020.12.002.

  17. Ou HL, Schumacher B. (2021) Evaluating DNA damage response through immunofluorescence staining of primordial germ cells in Caenorhabditis elegans L1 larva. STAR Protoc. 2021 Apr 5;2(2):100441. doi: 10.1016/j.xpro.2021.100441. eCollection 2021 Jun 18.

  18. Schumacher B, Pothof J, Vijg J, Hoeijmakers JHJ. (2021) The central role of DNA damage in the ageing process. Nature. 2021 Apr;592(7856):695-703. doi: 10.1038/s41586-021-03307-7. Epub 2021 Apr 28.

  19. Rieckher M, Garinis GA, Schumacher B. (2021) Molecular pathology of rare progeroid diseases. Trends Mol Med. 2021 Sep;27(9):907-922. doi: 10.1016/j.molmed.2021.06.011. Epub 2021 Jul 13.

  20. Soltanmohammadi N, Wang S, Schumacher B. (2022) Somatic PMK-1/p38 signaling links environmental stress to germ cell apoptosis and heritable euploidy. Nat Commun. 2022 Feb 4;13(1):701. doi: 10.1038/s41467-022-28225-8.

  21. Umansky C, Morellato AE, Rieckher M, Scheidegger MA, Martinefski MR, Fernández GA, Pak O, Kolesnikova K, Reingruber H, Bollini M, Crossan GP, Sommer N, Monge ME, Schumacher B, Pontel LB. (2022) Endogenous formaldehyde scavenges cellular glutathione resulting in redox disruption and cytotoxicity. Nat Commun. 2022 Feb 8;13(1):745. doi: 10.1038/s41467-022-28242-7.

  22. Volatier T, Schumacher B, Cursiefen C, Notara M. (2022) UV Protection in the Cornea: Failure and Rescue. Biology (Basel). 2022 Feb 10;11(2):278. doi: 10.3390/biology11020278.

  23. Vaddavalli PL, Schumacher B. (2022) The p53 network: cellular and systemic DNA damage responses in cancer and aging. Trends Genet. 2022 Jun;38(6):598-612. doi: 10.1016/j.tig.2022.02.010. Epub 2022 Mar 25.

  24. Kasper P, Selle J, Vohlen C, Wilke R, Kuiper-Makris C, Klymenko O, Bae-Gartz I, Schömig C, Quaas A, Schumacher B, Demir M, Bürger M, Lang S, Martin A, Steffen HM, Goeser T, Dötsch J, Alcazar MAA. (2022) Perinatal Obesity Induces Hepatic Growth Restriction with Increased DNA Damage Response, Senescence, and Dysregulated Igf-1-Akt-Foxo1 Signaling in Male Offspring of Obese Mice. Int J Mol Sci. 2022 May 17;23(10):5609. doi: 10.3390/ijms23105609.

  25. Wang S, Meyer DH, Schumacher B. (2023) Inheritance of paternal DNA damage by histone-mediated repair restriction. Nature. 2023 Jan;613(7943):365-374. doi: 10.1038/s41586-022-05544-w. Epub 2022 Dec 21.

  26. Soltanmohammadi N, Wang S, Schumacher B. (2023) Author Correction: Somatic PMK-1/p38 signaling links environmental stress to germ cell apoptosis and heritable euploidy. Nat Commun. 2023 Jan 17;14(1):270. doi: 10.1038/s41467-023-35831-7.

  27. Clahsen T, Hadrian K, Notara M, Schlereth SL, Howaldt A, Prokosch V, Volatier T, Hos D, Schroedl F, Kaser-Eichberger A, Heindl LM, Steven P, Bosch JJ, Steinkasserer A, Rokohl AC, Liu H, Mestanoglu M, Kashkar H, Schumacher B, Kiefer F, Schulte-Merker S, Matthaei M, Hou Y, Fassbender S, Jantsch J, Zhang W, Enders P, Bachmann B, Bock F, Cursiefen C. (2023) The novel role of lymphatic vessels in the pathogenesis of ocular diseases. Prog Retin Eye Res. 2023 Sep;96:101157. doi: 10.1016/j.preteyeres.2022.101157. Epub 2023 Feb 8.

  28. Selle J, Bohl K, Höpker K, Wilke R, Dinger K, Kasper P, Abend B, Schermer B, Müller RU, Kurschat C, Nüsken KD, Nüsken E, Meyer D, Savai Pullamsetti S, Schumacher B, Dötsch J, Alcazar MAA. (2023) Perinatal Obesity Sensitizes for Premature Kidney Aging Signaling. Int J Mol Sci. 2023 Jan 28;24(3):2508. doi: 10.3390/ijms24032508.

  29. Volatier T, Schumacher B, Meshko B, Hadrian K, Cursiefen C, Notara M. (2023) Short-Term UVB Irradiation Leads to Persistent DNA Damage in Limbal Epithelial Stem Cells, Partially Reversed by DNA Repairing Enzymes. Biology (Basel). 2023 Feb 7;12(2):265. doi: 10.3390/biology12020265.

  30. Bujarrabal-Dueso A, Sendtner G, Meyer DH, Chatzinikolaou G, Stratigi K, Garinis GA, Schumacher B. (2023) The DREAM complex functions as conserved master regulator of somatic DNA-repair capacities. Nat Struct Mol Biol. 2023 Apr;30(4):475-488. doi: 10.1038/s41594-023-00942-8. Epub 2023 Mar 23.

  31. Vijg J, Schumacher B, Abakir A, Antonov M, Bradley C, Cagan A, Church G, Gladyshev VN, Gorbunova V, Maslov AY, Reik W, Sharifi S, Suh Y, Walsh K. (2023) Mitigating age-related somatic mutation burden. Trends Mol Med. 2023 Jul;29(7):530-540. doi: 10.1016/j.molmed.2023.04.002. Epub 2023 Apr 29.

  32. Benzing T, Schumacher B. (2023) Chronic kidney disease promotes ageing in a multiorgan disease network. Nat Rev Nephrol. 2023 Sep;19(9):542-543. doi: 10.1038/s41581-023-00729-6.

  33. Panier S, Wang S, Schumacher B. (2024) Genome Instability and DNA Repair in Somatic and Reproductive Aging. Annu Rev Pathol. 2024 Jan 24;19:261-290. doi: 10.1146/annurev-pathmechdis-051122-093128. Epub 2023 Oct 13.

  34. Gallrein C, Williams AB, Meyer DH, Messling JE, Garcia A, Schumacher B. (2023) baz-2 enhances systemic proteostasis in vivo by regulating acetylcholine metabolism. Cell Rep. 2023 Dec 26;42(12):113577. doi: 10.1016/j.celrep.2023.113577. Epub 2023 Dec 14.

  35. Arvanitaki ES, Goulielmaki E, Gkirtzimanaki K, Niotis G, Tsakani E, Nenedaki E, Rouska I, Kefalogianni M, Xydias D, Kalafatakis I, Psilodimitrakopoulos S, Karagogeos D, Schumacher B, Stratakis E, Garinis GA. (2024) Microglia-derived extracellular vesicles trigger age-related neurodegeneration upon DNA damage. Proc Natl Acad Sci U S A. 2024 Apr 23;121(17):e2317402121. doi: 10.1073/pnas.2317402121. Epub 2024 Apr 18.

  36. Ropert B, Gallrein C, Schumacher B. (2024) DNA repair deficiencies and neurodegeneration. DNA Repair (Amst). 2024 Jun;138:103679. doi: 10.1016/j.dnarep.2024.103679. Epub 2024 Apr 16.

  37. Meyer DH, Schumacher B. (2024) Aging clocks based on accumulating stochastic variation. Nat Aging. 2024 Jun;4(6):871-885. doi: 10.1038/s43587-024-00619-x. Epub 2024 May 9.

  38. Siametis A, Stratigi K, Giamaki D, Chatzinikolaou G, Akalestou-Clocher A, Goulielmaki E, Luke B, Schumacher B, Garinis GA. (2024) Transcription stress at telomeres leads to cytosolic DNA release and paracrine senescence. Nat Commun. 2024 May 14;15(1):4061. doi: 10.1038/s41467-024-48443-6.

  39. Rieckher M, Gallrein C, Alquezar-Artieda N, Bourached-Silva N, Vaddavalli PL, Mares D, Backhaus M, Blindauer T, Greger K, Wiesner E, Pontel LB, Schumacher B. (2024) Distinct DNA repair mechanisms prevent formaldehyde toxicity during development, reproduction and aging. Nucleic Acids Res. 2024 Aug 12;52(14):8271-8285. doi: 10.1093/nar/gkae519.

  40. Molière A, Park JYC, Goyala A, Vayndorf EM, Zhang B, Hsiung KC, Jung Y, Kwon S, Statzer C, Meyer D, Nguyen R, Chadwick J, Thompson MA, Schumacher B, Lee SV, Essmann CL, MacArthur MR, Kaeberlein M, David D, Gems D, Ewald CY. (2024) Improved resilience and proteostasis mediate longevity upon DAF-2 degradation in old age. Geroscience. 2024 Oct;46(5):5015-5036. doi: 10.1007/s11357-024-01232-x. Epub 2024 Jun 20.

  41. Lyu YX, Fu Q, Wilczok D, Ying K, King A, Antebi A, Vojta A, Stolzing A, Moskalev A, Georgievskaya A, Maier AB, Olsen A, Groth A, Simon AK, Brunet A, Jamil A, Kulaga A, Bhatti A, Yaden B, Pedersen BK, Schumacher B, Djordjevic B, Kennedy B, Chen C, Huang CY, Correll CU, Murphy CT, Ewald CY, Chen D, Valenzano DR, Sołdacki D, Erritzoe D, Meyer D, Sinclair DA, Chini EN, Teeling EC, Morgen E, Verdin E, Vernet E, Pinilla E, Fang EF, Bischof E, Mercken EM, Finger F, Kuipers F, Pun FW, Gyülveszi G, Civiletto G, Zmudze G, Blander G, Pincus HA, McClure J, Kirkland JL, Peyer J, Justice JN, Vijg J, Gruhn JR, McLaughlin J, Mannick J, Passos J, Baur JA, Betts-LaCroix J, Sedivy JM, Speakman JR, Shlain J, von Maltzahn J, Andreasson KI, Moody K, Palikaras K, Fortney K, Niedernhofer LJ, Rasmussen LJ, Veenhoff LM, Melton L, Ferrucci L, Quarta M, Koval M, Marinova M, Hamalainen M, Unfried M, Ringel MS, Filipovic M, Topors M, Mitin N, Roy N, Pintar N, Barzilai N, Binetti P, Singh P, Kohlhaas P, Robbins PD, Rubin P, Fedichev PO, Kamya P, Muñoz-Canoves P, de Cabo R, Faragher RGA, Konrad R, Ripa R, Mansukhani R, Büttner S, Wickström SA, Brunemeier S, Jakimov S, Luo S, Rosenzweig-Lipson S, Tsai SY, … (2024) Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity. Aging (Albany NY). 2024 Oct 16;16(20):12955-12976. doi: 10.18632/aging.206135. Epub 2024 Oct 16.

  42. Jacques E, Herzog C, Ying K, Tomusiak A, Kasamoto J, Sehgal R, Paulson S, Reinhard J, Träuble J, Hastings WJ, Tyshkovskiy A, Hägg S, Earls JC, Behrens CE, Lasky-Su J, Zhou G, Morgen E, Tsang JS, Marioni RE, Ma XJ, Stolzing A, Glorioso C, Gootenberg JS, Abudayyeh OO, Argentieri MA, Mak RH, Cox LS, Brack AS, Lauc G, Furman D, Buenrostro JD, Schumacher B, Justice JN, Woods T, Gobel D, Perez VI, Sinclair DA, Maier AB, Barzilai N, Snyder MP, Wyss-Coray T, Horvath S, Ferrucci L, Poganik JR, Moqri M, Gladyshev VN. (2025) Invigorating discovery and clinical translation of aging biomarkers. Nat Aging. 2025 Apr;5(4):539-543. doi: 10.1038/s43587-025-00838-w.

  43. Meyer DH, Schumacher B. (2025) The stochasticity of biological aging. Nat Med. 2025 Jun;31(6):1735-1736. doi: 10.1038/s41591-025-03687-7.

  44. Braun F, Mandel AM, Blomberg L, Wong MN, Chatzinikolaou G, Meyer DH, Reinelt A, Nair V, Akbar-Haase R, McCown PJ, Haas F, Chen H, Rahmatollahi M, Fermin D, Ebbestad R, Slaats GG, Bork T, Schell C, Koehler S, Brinkkoetter PT, Lindenmeyer MT, Cohen CD, Kann M, Unnersjö-Jess D, Bloch W, Sampson MG, Dollé ME, Puelles VG, Kretzler M, Garinis GA, Huber TB, Schermer B, Benzing T, Schumacher B, Kurschat CE. (2025) Loss of genome maintenance is linked to mTOR complex 1 signaling and accelerates podocyte damage. JCI Insight. 2025 May 20;10(12):e172370. doi: 10.1172/jci.insight.172370. eCollection 2025 Jun 23.

  45. Bujarrabal-Dueso A, Garinis GA, Robbins PD, Vijg J, Schumacher B. (2025) Targeting DNA damage in ageing: towards supercharging DNA repair. Nat Rev Drug Discov. 2025 Oct;24(10):785-807. doi: 10.1038/s41573-025-01212-6. Epub 2025 Jun 12.

  46. Ishikawa S, Schumacher B. (2025) The Somatic Impact on Inheritance and the Germline Control of the Soma. Annu Rev Genet. 2025 Nov;59(1):91-117. doi: 10.1146/annurev-genet-020325-040022. Epub 2025 Jul 16.

  47. Meyer DH, Maklakov AA, Schumacher B. (2025) Aging by the clock and yet without a program. Nat Aging. 2025 Oct;5(10):1946-1956. doi: 10.1038/s43587-025-00975-2. Epub 2025 Sep 18.

  48. Toiber D, Schumacher B. (2026) Targeting Genome Stability to Mitigate Human Aging and Disease. Annu Rev Pathol. 2026 Jan;21(1):213-238. doi: 10.1146/annurev-pathmechdis-042624-105942. Epub 2025 Oct 14.

  49. Totska K, Barata JCVV, Sandt W, Meyer DH, Schumacher B. (2025) Age Deceleration and Reversal Gene Patterns in Dauer Diapause. Aging Cell. 2025 Dec;24(12):e70253. doi: 10.1111/acel.70253. Epub 2025 Oct 17.

  50. Basu A, Thorsten P, Schumacher B, Kletsas D, Scharffetter-Kochanek K. (2025) The dark side of the light (UVA): melanoma microenvironment and cell survival strategies. Cell Death Discov. 2025 Oct 20;11(1):466. doi: 10.1038/s41420-025-02751-y.

  51. Basu A, Farsam V, Singh K, Crisan D, Treiber N, Schneider LA, Huber M, Engelmeyer JI, Schumacher B, Maity P, Brandt D, Jastroch M, Mauch C, Geiger H, Kletsas D, Scharffetter-Kochanek K. (2025) Senescent Fibroblasts Drive Melanoma Progression Through GCP-2 Induced CREB Phosphorylation Enhancing Glycolysis. Aging Cell. 2025 Dec;24(12):e70239. doi: 10.1111/acel.70239. Epub 2025 Nov 19.

  52. Meyer DH, Maklakov AA, Schumacher B. (2025) Addendum: Aging by the clock and yet without a program. Nat Aging. 2025 Dec 15. doi: 10.1038/s43587-025-01050-6. Online ahead of print.

  53. Gallrein C, Meyer DH, Woitzat Y, Ramirez-Ramirez V, Vuong-Brender T, Kirstein J, Schumacher B. (2026) Aging clocks delineate neuron types vulnerable or resilient to neurodegeneration and identify neuroprotective interventions. Nat Aging. 2026 Feb 3. doi: 10.1038/s43587-026-01067-5. Online ahead of print.

Prof. Sivan Henis-Korenblit
Prof. Sivan Henis-Korenblit

Prof. Sivan Henis - Korenblit

Aging and Proteostasis

  1. Henis-Korenblit S, Meléndez A. (2019) Methods to Determine the Role of Autophagy Proteins in C. elegans Aging. Methods Mol Biol. 2019;1880:561-586. doi: 10.1007/978-1-4939-8873-0_37.

  2. Barak R, Yom-Tov G, Guez-Haddad J, Gasri-Plotnitsky L, Maimon R, Cohen-Berkman M, McCarthy AA, Perlson E, Henis-Korenblit S, Isupov MN, Opatowsky Y. (2019) Structural Principles in Robo Activation and Auto-inhibition. Cell. 2019 Apr 4;177(2):272-285.e16. doi: 10.1016/j.cell.2019.02.004. Epub 2019 Mar 7.

  3. Haviv-Chesner A, Henis-Korenblit S. (2019) Turning off the Wnt-a dietary restriction switch for healthy aging. EMBO Rep. 2019 May;20(5):e48114. doi: 10.15252/embr.201948114. Epub 2019 Apr 23.

  4. Cohen-Berkman M, Dudkevich R, Ben-Hamo S, Fishman A, Salzberg Y, Waldman Ben-Asher H, Lamm AT, Henis-Korenblit S. (2020). Endogenous siRNAs promote proteostasis and longevity in germline-less Caenorhabditis elegans. Elife. 2020 Mar 26;9:e50896. DOI: 10.7554/eLife.50896

  5. Adir O, Bening-Abu-Shach U, Arbib S, Henis-Korenblit S, Broday L. (2020) Inactivation of the Caenorhabditis elegans RNF-5 E3 ligase promotes IRE-1-independent ER functions. Autophagy 1-14. DOI: 10.1080/15548627.2020.1827778.

  6. Levi-Ferber M, Shalash R, Le-Thomas A, Salzberg Y, Shurgi M, Benichou JI, Ashkenazi A, Henis-Korenblit S. (2021) Neuronal regulated ire-1-dependent mRNA decay controls germline differentiation in Caenorhabditis elegans. Elife. 2021 Sep 3;10:e65644.  DOI: 10.7554/eLife.65644

  7. Reut Dudkevich, Jhee Hong Koh, Caroline Beaudoin-Chabo, Cenk Celik, Ilana Lebenthal-Loinger, Sarit Karako-Lampert, Guillaume Thibault and Sivan Henis-Korenblit. Neuronal IRE-1 coordinates an organism-wide cold stress response by regulating fat metabolism. doi: 10.1016/j.celrep.2022.111739. DOI: 10.1016/j.celrep.2022.111739

  8. R Shalash, M Levi-Ferber, C Cohen, A Dori, C Brodie*, S Henis-Korenblit*(2024) Cross-species modeling of muscular dystrophy in Caenorhabditis elegans using patient-derived extracellular vesicles. Disease Models & Mechanisms 17 (3). DOI: 10.1242/dmm.050412

  9. Zelikman S, Dudkevich R, Korenfeld-Tzemach H, Shmidov E, Levi-Ferber M, Shoshani S, Ben-Aroya S, Henis-Korenblit S*, Banin E*. (2024) PemB, a type III secretion effector in Pseudomonas aeruginosa, affects Caenorhabditis elegans life span. Heliyon 10(8):e29751. DOI: 10.1016/j.heliyon.2024.e29751

  10. Shalash R, Solomon DM, Levi-Ferber M, von Chrzanowski H, Atrash MK, Nakar B, Avivi MY, Hauschner H, Swisa A, Meléndez A, Shav-Tal Y, Henis-Korenblit S. (2025)  HLH-30/TFEB Rewires the Chaperone Network to Promote Proteostasis Upon Perturbations to the Coenzyme A and Iron-Sulfur Cluster Biosynthesis Pathways. Aging Cell. 2025 Jun;24(6):e70038. DOI: 10.1111/acel.70038.

  11. Marchoom-Bura N, Zelikman S, Morgenstern D, Levin Y, Barbiro-Michaely E, Banin E, Henis-Korenblit S, Gerber D. (2025). Integrated Microfluidic Platform for Longitudinal Imaging, Functional Assays, and Downstream Proteomics in C. elegans. Small. 21(43): e06108. DOI: 10.1002/smll.202506108

Prof. Dr. Jens C. Brüning

Prof. Dr. Jens C. Brüning

Aging and Metabolism

Prof. Dr. Jens C. Brüning

  1. Thanarajah SE, Backes H, DiFeliceantonio AG, Albus K, Cremer AL, Hanssen R, Lippert RN, Cornely OA, Small DM, Brüning JC, Tittgemeyer M. (2019) Food Intake Recruits Orosensory and Post-ingestive Dopaminergic Circuits to Affect Eating Desire in Humans. Cell Metab. 2019 Mar 5;29(3):695-706.e4. doi: 10.1016/j.cmet.2018.12.006. Epub 2018 Dec 27.

  2. Turpin-Nolan SM, Hammerschmidt P, Chen W, Jais A, Timper K, Awazawa M, Brodesser S, Brüning JC. (2019) CerS1-Derived C18:0 Ceramide in Skeletal Muscle Promotes Obesity-Induced Insulin Resistance. Cell Rep. 2019 Jan 2;26(1):1-10.e7. doi: 10.1016/j.celrep.2018.12.031.

  3. Raichur S, Brunner B, Bielohuby M, Hansen G, Pfenninger A, Wang B, Bruning JC, Larsen PJ, Tennagels N. (2019) The role of C16:0 ceramide in the development of obesity and type 2 diabetes: CerS6 inhibition as a novel therapeutic approach. Mol Metab. 2019 Mar;21:36-50. doi: 10.1016/j.molmet.2018.12.008. Epub 2019 Jan 2.

  4. Lippert RN, Cremer AL, Edwin Thanarajah S, Korn C, Jahans-Price T, Burgeno LM, Tittgemeyer M, Brüning JC, Walton ME, Backes H. (2019) Time-dependent assessment of stimulus-evoked regional dopamine release. Nat Commun. 2019 Jan 18;10(1):336. doi: 10.1038/s41467-018-08143-4.

  5. Wang L, De Solis AJ, Goffer Y, Birkenbach KE, Engle SE, Tanis R, Levenson JM, Li X, Rausch R, Purohit M, Lee JY, Tan J, De Rosa MC, Doege CA, Aaron HL, Martins GJ, Brüning JC, Egli D, Costa R, Berbari N, Leibel RL, Stratigopoulos G. (2019) Ciliary gene RPGRIP1L is required for hypothalamic arcuate neuron development. JCI Insight. 2019 Feb 7;4(3):e123337. doi: 10.1172/jci.insight.123337.

  6. Edwin Thanarajah S, Iglesias S, Kuzmanovic B, Rigoux L, Stephan KE, Brüning JC, Tittgemeyer M. (2019) Modulation of midbrain neurocircuitry by intranasal insulin. Neuroimage. 2019 Jul 1;194:120-127. doi: 10.1016/j.neuroimage.2019.03.050. Epub 2019 Mar 23.

  7. Ip CK, Zhang L, Farzi A, Qi Y, Clarke I, Reed F, Shi YC, Enriquez R, Dayas C, Graham B, Begg D, Brüning JC, Lee NJ, Hernandez-Sanchez D, Gopalasingam G, Koller J, Tasan R, Sperk G, Herzog H. (2019) Amygdala NPY Circuits Promote the Development of Accelerated Obesity under Chronic Stress Conditions. Cell Metab. 2019 Jul 2;30(1):111-128.e6. doi: 10.1016/j.cmet.2019.04.001. Epub 2019 Apr 25.

  8. Edwin Thanarajah S, Hoffstall V, Rigoux L, Hanssen R, Brüning JC, Tittgemeyer M. (2019) The role of insulin sensitivity and intranasally applied insulin on olfactory perception. Sci Rep. 2019 May 10;9(1):7222. doi: 10.1038/s41598-019-43693-7.

  9. Hammerschmidt P, Ostkotte D, Nolte H, Gerl MJ, Jais A, Brunner HL, Sprenger HG, Awazawa M, Nicholls HT, Turpin-Nolan SM, Langer T, Krüger M, Brügger B, Brüning JC. (2019) CerS6-Derived Sphingolipids Interact with Mff and Promote Mitochondrial Fragmentation in Obesity. Cell. 2019 May 30;177(6):1536-1552.e23. doi: 10.1016/j.cell.2019.05.008.

  10. Ruud J, Alber J, Tokarska A, Engström Ruud L, Nolte H, Biglari N, Lippert R, Lautenschlager Ä, Cieślak PE, Szumiec Ł, Hess ME, Brönneke HS, Krüger M, Nissbrandt H, Korotkova T, Silberberg G, Rodriguez Parkitna J, Brüning JC. (2019) The Fat Mass and Obesity-Associated Protein (FTO) Regulates Locomotor Responses to Novelty via D2R Medium Spiny Neurons. Cell Rep. 2019 Jun 11;27(11):3182-3198.e9. doi: 10.1016/j.celrep.2019.05.037.

  11. Ding X, Willenborg S, Bloch W, Wickström SA, Wagle P, Brodesser S, Roers A, Jais A, Brüning JC, Hall MN, Rüegg MA, Eming SA. (2019) Epidermal mammalian target of rapamycin complex 2 controls lipid synthesis and filaggrin processing in epidermal barrier formation. J Allergy Clin Immunol. 2020 Jan;145(1):283-300.e8. doi: 10.1016/j.jaci.2019.07.033. Epub 2019 Aug 8.

  12. Cheng Y, Luo H, Izzo F, Pickering BF, Nguyen D, Myers R, Schurer A, Gourkanti S, Brüning JC, Vu LP, Jaffrey SR, Landau DA, Kharas MG. (2019) m6A RNA Methylation Maintains Hematopoietic Stem Cell Identity and Symmetric Commitment. Cell Rep. 2019 Aug 13;28(7):1703-1716.e6. doi: 10.1016/j.celrep.2019.07.032.

  13. MacVicar T, Ohba Y, Nolte H, Mayer FC, Tatsuta T, Sprenger HG, Lindner B, Zhao Y, Li J, Bruns C, Krüger M, Habich M, Riemer J, Schwarzer R, Pasparakis M, Henschke S, Brüning JC, Zamboni N, Langer T. (2019) Lipid signalling drives proteolytic rewiring of mitochondria by YME1L. Nature. 2019 Nov;575(7782):361-365. doi: 10.1038/s41586-019-1738-6. Epub 2019 Nov 6.

  14. Engström Ruud L, Pereira MMA, de Solis AJ, Fenselau H, Brüning JC. (2020) NPY mediates the rapid feeding and glucose metabolism regulatory functions of AgRP neurons. Nat Commun. 2020 Jan 23;11(1):442. doi: 10.1038/s41467-020-14291-3.

  15. Turpin-Nolan SM, Brüning JC. (2020) The role of ceramides in metabolic disorders: when size and localization matters. Nat Rev Endocrinol. 2020 Apr;16(4):224-233. doi: 10.1038/s41574-020-0320-5. Epub 2020 Feb 14.

  16. Jais A, Paeger L, Sotelo-Hitschfeld T, Bremser S, Prinzensteiner M, Klemm P, Mykytiuk V, Widdershooven PJM, Vesting AJ, Grzelka K, Minère M, Cremer AL, Xu J, Korotkova T, Lowell BB, Zeilhofer HU, Backes H, Fenselau H, Wunderlich FT, Kloppenburg P, Brüning JC. (2020) PNOCARC Neurons Promote Hyperphagia and Obesity upon High-Fat-Diet Feeding. Neuron. 2020 Jun 17;106(6):1009-1025.e10. doi: 10.1016/j.neuron.2020.03.022. Epub 2020 Apr 16.

  17. Fischer K, Fenzl A, Liu D, Dyar KA, Kleinert M, Brielmeier M, Clemmensen C, Fedl A, Finan B, Gessner A, Jastroch M, Huang J, Keipert S, Klingenspor M, Brüning JC, Kneilling M, Maier FC, Othman AE, Pichler BJ, Pramme-Steinwachs I, Sachs S, Scheideler A, Thaiss WM, Uhlenhaut H, Ussar S, Woods SC, Zorn J, Stemmer K, Collins S, Diaz-Meco M, Moscat J, Tschöp MH, Müller TD. (2020) The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation. Nat Commun. 2020 May 8;11(1):2306. doi: 10.1038/s41467-020-16230-8.

  18. Jiang H, Gallet S, Klemm P, Scholl P, Folz-Donahue K, Altmüller J, Alber J, Heilinger C, Kukat C, Loyens A, Müller-Fielitz H, Sundaram S, Schwaninger M, Prevot V, Brüning JC. (2020) MCH Neurons Regulate Permeability of the Median Eminence Barrier. Neuron. 2020 Jul 22;107(2):306-319.e9. doi: 10.1016/j.neuron.2020.04.020. Epub 2020 May 13.

  19. Timper K, Del Río-Martín A, Cremer AL, Bremser S, Alber J, Giavalisco P, Varela L, Heilinger C, Nolte H, Trifunovic A, Horvath TL, Kloppenburg P, Backes H, Brüning JC. (2020) GLP-1 Receptor Signaling in Astrocytes Regulates Fatty Acid Oxidation, Mitochondrial Integrity, and Function. Cell Metab. 2020 Jun 2;31(6):1189-1205.e13. doi: 10.1016/j.cmet.2020.05.001. Epub 2020 May 19.

  20. Mittenbühler MJ, Saedler K, Nolte H, Kern L, Zhou J, Qian SB, Meder L, Ullrich RT, Brüning JC, Wunderlich FT. (2020) Hepatic FTO is dispensable for the regulation of metabolism but counteracts HCC development in vivo. Mol Metab. 2020 Dec;42:101085. doi: 10.1016/j.molmet.2020.101085. Epub 2020 Sep 19.

  21. Hanssen R, Kretschmer AC, Rigoux L, Albus K, Edwin Thanarajah S, Sitnikow T, Melzer C, Cornely OA, Brüning JC, Tittgemeyer M. (2021) GLP-1 and hunger modulate incentive motivation depending on insulin sensitivity in humans. Mol Metab. 2021 Mar;45:101163. doi: 10.1016/j.molmet.2021.101163. Epub 2021 Jan 14.

  22. Kohlhaas V, Blakemore SJ, Al-Maarri M, Nickel N, Pal M, Roth A, Hövelmeyer N, Schäfer SC, Knittel G, Lohneis P, Nikolic M, Wiederstein JL, Franitza M, Georgomonolis T, Reinart N, Herling M, Herling C, Hartmann EM, Rosenwald A, Klapper W, Büttner R, Moia R, Rossi D, Boldorini R, Gaidano G, Frenzel LP, Reinhardt HC, Brüning JC, Hallek M, Krüger M, Peifer M, Pallasch CP, Wunderlich FT. (2021) Active Akt signaling triggers CLL toward Richter transformation via overactivation of Notch1. Blood. 2021 Feb 4;137(5):646-660. doi: 10.1182/blood.2020005734.

  23. Quarta C, Claret M, Zeltser LM, Williams KW, Yeo GSH, Tschöp MH, Diano S, Brüning JC, Cota D. (2021) POMC neuronal heterogeneity in energy balance and beyond: an integrated view. Nat Metab. 2021 Mar;3(3):299-308. doi: 10.1038/s42255-021-00345-3. Epub 2021 Feb 25.

  24. Dodd GT, Kim SJ, Méquinion M, Xirouchaki CE, Brüning JC, Andrews ZB, Tiganis T. (2021) Insulin signaling in AgRP neurons regulates meal size to limit glucose excursions and insulin resistance. Sci Adv. 2021 Feb 26;7(9):eabf4100. doi: 10.1126/sciadv.abf4100. Print 2021 Feb.

  25. Biglari N, Gaziano I, Schumacher J, Radermacher J, Paeger L, Klemm P, Chen W, Corneliussen S, Wunderlich CM, Sue M, Vollmar S, Klöckener T, Sotelo-Hitschfeld T, Abbasloo A, Edenhofer F, Reimann F, Gribble FM, Fenselau H, Kloppenburg P, Wunderlich FT, Brüning JC. (2021) Functionally distinct POMC-expressing neuron subpopulations in hypothalamus revealed by intersectional targeting. Nat Neurosci. 2021 Jul;24(7):913-929. doi: 10.1038/s41593-021-00854-0. Epub 2021 May 17.

  26. Borgmann D, Ciglieri E, Biglari N, Brandt C, Cremer AL, Backes H, Tittgemeyer M, Wunderlich FT, Brüning JC, Fenselau H. (2021) Gut-brain communication by distinct sensory neurons differently controls feeding and glucose metabolism. Cell Metab. 2021 Jul 6;33(7):1466-1482.e7. doi: 10.1016/j.cmet.2021.05.002. Epub 2021 May 26.

  27. Lippert RN, Brüning JC. (2021) Maternal Metabolic Programming of the Developing Central Nervous System: Unified Pathways to Metabolic and Psychiatric Disorders. Biol Psychiatry. 2022 May 15;91(10):898-906. doi: 10.1016/j.biopsych.2021.06.002. Epub 2021 Jun 8.

  28. Xiao X, Yeghiazaryan G, Hess S, Klemm P, Sieben A, Kleinridders A, Morgan DA, Wunderlich FT, Rahmouni K, Kong D, Scammell TE, Lowell BB, Kloppenburg P, Brüning JC, Hausen AC. (2021) Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity. Nat Commun. 2021 Sep 2;12(1):5249. doi: 10.1038/s41467-021-25380-2.

  29. Welcker D, Stein C, Feitosa NM, Armistead J, Zhang JL, Lütke S, Kleinridders A, Brüning JC, Eming SA, Sengle G, Niehoff A, Bloch W, Hammerschmidt M. (2021) Hemicentin-1 is an essential extracellular matrix component of the dermal-epidermal and myotendinous junctions. Sci Rep. 2021 Sep 9;11(1):17926. doi: 10.1038/s41598-021-96824-4.

  30. Willenborg S, Sanin DE, Jais A, Ding X, Ulas T, Nüchel J, Popović M, MacVicar T, Langer T, Schultze JL, Gerbaulet A, Roers A, Pearce EJ, Brüning JC, Trifunovic A, Eming SA. (2021) Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing. Cell Metab. 2021 Dec 7;33(12):2398-2414.e9. doi: 10.1016/j.cmet.2021.10.004. Epub 2021 Oct 28.

  31. Porniece Kumar M, Cremer AL, Klemm P, Steuernagel L, Sundaram S, Jais A, Hausen AC, Tao J, Secher A, Pedersen TÅ, Schwaninger M, Wunderlich FT, Lowell BB, Backes H, Brüning JC. (2021) Insulin signalling in tanycytes gates hypothalamic insulin uptake and regulation of AgRP neuron activity. Nat Metab. 2021 Dec;3(12):1662-1679. doi: 10.1038/s42255-021-00499-0. Epub 2021 Dec 20.

  32. Jais A, Brüning JC. (2022) Arcuate Nucleus-Dependent Regulation of Metabolism-Pathways to Obesity and Diabetes Mellitus. Endocr Rev. 2022 Mar 9;43(2):314-328. doi: 10.1210/endrev/bnab025.

  33. Matsushita M, Awazawa M, Kobayashi N, Ikushima YM, Soeda K, Tamura-Nakano M, Muratani M, Kobayashi K, Blüher M, Brüning JC, Ueki K. (2022) An antisense transcript transcribed from Irs2 locus contributes to the pathogenesis of hepatic steatosis in insulin resistance. Cell Chem Biol. 2022 Apr 21;29(4):680-689.e6. doi: 10.1016/j.chembiol.2021.12.008. Epub 2022 Jan 4.

  34. Ramírez S, Haddad-Tóvolli R, Radosevic M, Toledo M, Pané A, Alcolea D, Ribas V, Milà-Guasch M, Pozo M, Obri A, Eyre E, Gómez-Valadés AG, Chivite I, Van Eeckhout T, Zalachoras I, Altirriba J, Bauder C, Imbernón M, Garrabou G, Garcia-Ruiz C, Nogueiras R, Soto D, Gasull X, Sandi C, Brüning JC, Fortea J, Jiménez A, Fernández-Checa JC, Claret M. (2022) Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders. Cell Metab. 2022 Feb 1;34(2):269-284.e9. doi: 10.1016/j.cmet.2021.12.023.

  35. Fulzele K, Riddle RC, DiGirolamo DJ, Cao X, Wan C, Chen D, Faugere MC, Aja S, Hussain MA, Brüning JC, Clemens TL. (2022) Insulin Receptor Signaling in Osteoblasts Regulates Postnatal Bone Acquisition and Body Composition. Cell. 2022 Feb 17;185(4):746. doi: 10.1016/j.cell.2022.01.016.

  36. Hanssen R, Thanarajah SE, Tittgemeyer M, Brüning JC. (2022) Obesity - A Matter of Motivation? Exp Clin Endocrinol Diabetes. 2022 May;130(5):290-295. doi: 10.1055/a-1749-4852. Epub 2022 Feb 18.

  37. Hammerschmidt P, Brüning JC. (2022) Contribution of specific ceramides to obesity-associated metabolic diseases. Cell Mol Life Sci. 2022 Jul 5;79(8):395. doi: 10.1007/s00018-022-04401-3.

  38. Steuernagel L, Lam BYH, Klemm P, Dowsett GKC, Bauder CA, Tadross JA, Hitschfeld TS, Del Rio Martin A, Chen W, de Solis AJ, Fenselau H, Davidsen P, Cimino I, Kohnke SN, Rimmington D, Coll AP, Beyer A, Yeo GSH, Brüning JC. (2022) HypoMap-a unified single-cell gene expression atlas of the murine hypothalamus. Nat Metab. 2022 Oct;4(10):1402-1419. doi: 10.1038/s42255-022-00657-y. Epub 2022 Oct 20.

  39. Gaziano I, Corneliussen S, Biglari N, Neuhaus R, Shen L, Sotelo-Hitschfeld T, Klemm P, Steuernagel L, De Solis AJ, Chen W, Wunderlich FT, Kloppenburg P, Brüning JC. (2022) Dopamine-inhibited POMCDrd2+ neurons in the ARC acutely regulate feeding and body temperature. JCI Insight. 2022 Nov 8;7(21):e162753. doi: 10.1172/jci.insight.162753.

  40. Vesting AJ, Jais A, Klemm P, Steuernagel L, Wienand P, Fog-Tonnesen M, Hvid H, Schumacher AL, Kukat C, Nolte H, Georgomanolis T, Altmüller J, Pasparakis M, Schmidt A, Krüger M, Supprian MS, Waisman A, Straub BK, Raschzok N, Bernier M, Birkenfeld AL, Hövelmeyer N, Brüning JC, Wunderlich FT. (2022) NIK/MAP3K14 in hepatocytes orchestrates NASH to hepatocellular carcinoma progression via JAK2/STAT5 inhibition. Mol Metab. 2022 Dec;66:101626. doi: 10.1016/j.molmet.2022.101626. Epub 2022 Nov 7.

  41. Griess K, Rieck M, Müller N, Karsai G, Hartwig S, Pelligra A, Hardt R, Schlegel C, Kuboth J, Uhlemeyer C, Trenkamp S, Jeruschke K, Weiss J, Peifer-Weiss L, Xu W, Cames S, Yi X, Cnop M, Beller M, Stark H, Kondadi AK, Reichert AS, Markgraf D, Wammers M, Häussinger D, Kuss O, Lehr S, Eizirik D, Lickert H, Lammert E, Roden M, Winter D, Al-Hasani H, Höglinger D, Hornemann T, Brüning JC, Belgardt BF. (2023) Sphingolipid subtypes differentially control proinsulin processing and systemic glucose homeostasis. Nat Cell Biol. 2023 Jan;25(1):20-29. doi: 10.1038/s41556-022-01027-2. Epub 2022 Dec 21.

  42. Teo JD, Marian OC, Spiteri AG, Nicholson M, Song H, Khor JXY, McEwen HP, Ge A, Sen MK, Piccio L, Fletcher JL, King NJC, Murray SS, Brüning JC, Don AS. (2023) Early microglial response, myelin deterioration and lethality in mice deficient for very long chain ceramide synthesis in oligodendrocytes. Glia. 2023 Apr;71(4):1120-1141. doi: 10.1002/glia.24329. Epub 2022 Dec 30.

  43. Hanssen R, Rigoux L, Albus K, Kretschmer AC, Edwin Thanarajah S, Chen W, Hinze Y, Giavalisco P, Steculorum SM, Cornely OA, Brüning JC, Tittgemeyer M. (2023) Circulating uridine dynamically and adaptively regulates food intake in humans. Cell Rep Med. 2023 Jan 17;4(1):100897. doi: 10.1016/j.xcrm.2022.100897.

  44. Parra-Vargas M, Bouret SG, Bruning JC, de Moura EG, Garland T Jr, Lisboa PC, Ozanne SE, Patti ME, Plagemann A, Speakman JR, Tena-Sempere M, Vergely C, Zeltser LM, Jiménez-Chillarón JC. (2023) The long-lasting shadow of litter size in rodents: litter size is an underreported variable that strongly determines adult physiology. Mol Metab. 2023 May;71:101707. doi: 10.1016/j.molmet.2023.101707. Epub 2023 Mar 16.

  45. Edwin Thanarajah S, DiFeliceantonio AG, Albus K, Kuzmanovic B, Rigoux L, Iglesias S, Hanßen R, Schlamann M, Cornely OA, Brüning JC, Tittgemeyer M, Small DM. (2023) Habitual daily intake of a sweet and fatty snack modulates reward processing in humans. Cell Metab. 2023 Apr 4;35(4):571-584.e6. doi: 10.1016/j.cmet.2023.02.015. Epub 2023 Mar 22.

  46. Chen W, Mehlkop O, Scharn A, Nolte H, Klemm P, Henschke S, Steuernagel L, Sotelo-Hitschfeld T, Kaya E, Wunderlich CM, Langer T, Kononenko NL, Giavalisco P, Brüning JC. (2023) Nutrient-sensing AgRP neurons relay control of liver autophagy during energy deprivation. Cell Metab. 2023 May 2;35(5):786-806.e13. doi: 10.1016/j.cmet.2023.03.019. Epub 2023 Apr 18.

  47. Hanssen R, Rigoux L, Kuzmanovic B, Iglesias S, Kretschmer AC, Schlamann M, Albus K, Edwin Thanarajah S, Sitnikow T, Melzer C, Cornely OA, Brüning JC, Tittgemeyer M. (2023) Liraglutide restores impaired associative learning in individuals with obesity. Nat Metab. 2023 Aug;5(8):1352-1363. doi: 10.1038/s42255-023-00859-y. Epub 2023 Aug 17.

  48. Brüning JC, Fenselau H. (2023) Integrative neurocircuits that control metabolism and food intake. Science. 2023 Sep 29;381(6665):eabl7398. doi: 10.1126/science.abl7398. Epub 2023 Sep 29.

  49. Hammerschmidt P, Steculorum SM, Bandet CL, Del Río-Martín A, Steuernagel L, Kohlhaas V, Feldmann M, Varela L, Majcher A, Quatorze Correia M, Klar RFU, Bauder CA, Kaya E, Porniece M, Biglari N, Sieben A, Horvath TL, Hornemann T, Brodesser S, Brüning JC. (2023) CerS6-dependent ceramide synthesis in hypothalamic neurons promotes ER/mitochondrial stress and impairs glucose homeostasis in obese mice. Nat Commun. 2023 Nov 29;14(1):7824. doi: 10.1038/s41467-023-42595-7.

  50. Vossen C, Schmidt P, Wunderlich CM, Mittenbühler MJ, Tapken C, Wienand P, Mirabella PN, Cabot L, Schumacher AL, Folz-Donahue K, Kukat C, Voigt I, Brüning JC, Fenselau H, Wunderlich FT. (2024) An Approach to Intersectionally Target Mature Enteroendocrine Cells in the Small Intestine of Mice. Cells. 2024 Jan 4;13(1):102. doi: 10.3390/cells13010102.

  51. De Solis AJ, Del Río-Martín A, Radermacher J, Chen W, Steuernagel L, Bauder CA, Eggersmann FR, Morgan DA, Cremer AL, Sué M, Germer M, Kukat C, Vollmar S, Backes H, Rahmouni K, Kloppenburg P, Brüning JC. (2024) Reciprocal activity of AgRP and POMC neurons governs coordinated control of feeding and metabolism. Nat Metab. 2024 Mar;6(3):473-493. doi: 10.1038/s42255-024-00987-z. Epub 2024 Feb 20.

  52. Engström Ruud L, Font-Gironès F, Zajdel J, Kern L, Teixidor-Deulofeu J, Mannerås-Holm L, Carreras A, Becattini B, Björefeldt A, Hanse E, Fenselau H, Solinas G, Brüning JC, Wunderlich TF, Bäckhed F, Ruud J. (2024) Activation of GFRAL+ neurons induces hypothermia and glucoregulatory responses associated with nausea and torpor. Cell Rep. 2024 Apr 23;43(4):113960. doi: 10.1016/j.celrep.2024.113960. Epub 2024 Mar 19.

  53. Springer C, Binsch C, Weide D, Toska L, Cremer AL, Backes H, Scheel AK, Espelage L, Kotzka J, Sill S, Kurowski A, Kim D, Karpinski S, Schnurr TM, Hansen T, Hartwig S, Lehr S, Cames S, Brüning JC, Lienhard M, Herwig R, Börno S, Timmermann B, Al-Hasani H, Chadt A. (2024) Depletion of TBC1D4 Improves the Metabolic Exercise Response by Overcoming Genetically Induced Peripheral Insulin Resistance. Diabetes. 2024 Jul 1;73(7):1058-1071. doi: 10.2337/db23-0463.

  54. Leon S, Simon V, Lee TH, Steuernagel L, Clark S, Biglari N, Lesté-Lasserre T, Dupuy N, Cannich A, Bellocchio L, Zizzari P, Allard C, Gonzales D, Le Feuvre Y, Lhuillier E, Brochard A, Nicolas JC, Teillon J, Nikolski M, Marsicano G, Fioramonti X, Brüning JC, Cota D, Quarta C. (2024) Single cell tracing of Pomc neurons reveals recruitment of 'Ghost' subtypes with atypical identity in a mouse model of obesity. Nat Commun. 2024 Apr 24;15(1):3443. doi: 10.1038/s41467-024-47877-2.

  55. Henschke S, Nolte H, Magoley J, Kleele T, Brandt C, Hausen AC, Wunderlich CM, Bauder CA, Aschauer P, Manley S, Langer T, Wunderlich FT, Brüning JC. (2024) Food perception promotes phosphorylation of MFFS131 and mitochondrial fragmentation in liver. Science. 2024 Apr 26;384(6694):438-446. doi: 10.1126/science.adk1005. Epub 2024 Apr 25.

  56. Sotelo-Hitschfeld T, Minère M, Klemm P, Borgmann D, Wnuk-Lipinski D, Jais A, Jia X, Corneliussen S, Kloppenburg P, Fenselau H, Brüning JC. (2024) GABAergic disinhibition from the BNST to PNOCARC neurons promotes HFD-induced hyperphagia. Cell Rep. 2024 Jun 25;43(6):114343. doi: 10.1016/j.celrep.2024.114343. Epub 2024 Jun 11.

  57. Zhou X, Stine C, Prada PO, Fusca D, Assoumou K, Dernic J, Bhat MA, Achanta AS, Johnson JC, Pasqualini AL, Jadhav S, Bauder CA, Steuernagel L, Ravotto L, Benke D, Weber B, Suko A, Palmiter RD, Stoeber M, Kloppenburg P, Brüning JC, Bruchas MR, Patriarchi T. (2024) Development of a genetically encoded sensor for probing endogenous nociceptin opioid peptide release. Nat Commun. 2024 Jun 25;15(1):5353. doi: 10.1038/s41467-024-49712-0.

  58. Dodt S, Widdershooven NV, Dreisow ML, Weiher L, Steuernagel L, Wunderlich FT, Brüning JC, Fenselau H. (2024) NPY-mediated synaptic plasticity in the extended amygdala prioritizes feeding during starvation. Nat Commun. 2024 Jun 27;15(1):5439. doi: 10.1038/s41467-024-49766-0.

  59. Ardanaz CG, de la Cruz A, Minhas PS, Hernández-Martín N, Pozo MÁ, Valdecantos MP, Valverde ÁM, Villa-Valverde P, Elizalde-Horcada M, Puerta E, Ramírez MJ, Ortega JE, Urbiola A, Ederra C, Ariz M, Ortiz-de-Solórzano C, Fernández-Irigoyen J, Santamaría E, Karsenty G, Brüning JC, Solas M. (2024) Astrocytic GLUT1 reduction paradoxically improves central and peripheral glucose homeostasis. Sci Adv. 2024 Oct 18;10(42):eadp1115. doi: 10.1126/sciadv.adp1115. Epub 2024 Oct 18.

  60. Amatruda M, Marechal D, Gacias M, Wentling M, Turpin-Nolan S, Morstein J, Moniruzzaman M, Brüning JC, Haughey NJ, Trauner DH, Casaccia P. (2025) Neuroprotective effect of neuron-specific deletion of the C16 ceramide synthetic enzymes in an animal model of multiple sclerosis. Glia. 2025 Feb;73(2):271-290. doi: 10.1002/glia.24631. Epub 2024 Nov 3.

  61. Tadross JA, Steuernagel L, Dowsett GKC, Kentistou KA, Lundh S, Porniece M, Klemm P, Rainbow K, Hvid H, Kania K, Polex-Wolf J, Knudsen LB, Pyke C, Perry JRB, Lam BYH, Brüning JC, Yeo GSH. (2025) A comprehensive spatio-cellular map of the human hypothalamus. Nature. 2025 Mar;639(8055):708-716. doi: 10.1038/s41586-024-08504-8. Epub 2025 Feb 5.

  62. Izawa S, Fusca D, Jiang H, Heilinger C, Hausen AC, Wunderlich FT, Steuernagel L, Kloppenburg P, Brüning JC. (2025) Orexin/hypocretin receptor 2 signaling in MCH neurons regulates REM sleep and insulin sensitivity. Cell Rep. 2025 Feb 25;44(2):115277. doi: 10.1016/j.celrep.2025.115277. Epub 2025 Feb 12.

  63. Jiao Z, Gao T, Wang X, Wang A, Ma Y, Feng L, Gao L, Gou L, Zhang W, Biglari N, Boxer EE, Steuernagel L, Ding X, Yu Z, Li M, Gao M, Hao M, Zhou H, Cao X, Li S, Jiang T, Qi J, Jia X, Feng Z, Ren B, Chen Y, Shi X, Wang D, Wang X, Han L, Liang Y, Qian L, Jin C, Huang J, Deng W, Wang C, Li E, Hu Y, Tao Z, Li H, Yu X, Xu M, Chang HC, Zhang Y, Xu H, Yan J, Li A, Luo Q, Stoop R, Sternson SM, Brüning JC, Anderson DJ, Poo MM, Sun Y, Xu S, Gong H, Sun YG, Xu X. (2025) Projectome-based characterization of hypothalamic peptidergic neurons in male mice. Nat Neurosci. 2025 May;28(5):1073-1088. doi: 10.1038/s41593-025-01919-0. Epub 2025 Mar 26.

  64. Zhu Y, Mehlkop O, Backes H, Cremer AL, Porniece M, Klemm P, Steuernagel L, Chen W, Johnen R, Wunderlich FT, Jais A, Brüning JC. (2025) Reduced Notch signaling in hypothalamic endothelial cells mediates obesity-induced alterations in glucose uptake and insulin signaling. Cell Rep. 2025 Apr 22;44(4):115522. doi: 10.1016/j.celrep.2025.115522. Epub 2025 Apr 3.

  65. Hof A, Landerer M, Peitsmeyer P, Herzog R, Alber J, Ahdab M, Nettersheim FS, Mehrkens D, Geißen S, Braumann S, Guthoff H, von Stein P, Nemade H, Picard FSR, Braun R, Hoyer FF, Brüning JC, Pfeifer A, Hildebrand S, Winkels H, Baldus S, Adam M, Schäkel J, Mollenhauer M. (2025) Myeloperoxidase impacts vascular function by altering perivascular adipocytes' secretome and phenotype in obesity. Cell Rep Med. 2025 May 20;6(5):102087. doi: 10.1016/j.xcrm.2025.102087. Epub 2025 Apr 18.

  66. Solheim MH, Stroganov S, Chen W, Subagia PS, Bauder CA, Wnuk-Lipinski D, Del Río-Martín A, Sotelo-Hitschfeld T, Beddows CA, Klemm P, Dodd GT, Lundh S, Secher A, Wunderlich FT, Steuernagel L, Brüning JC. (2025) Hypothalamic PNOC/NPY neurons constitute mediators of leptin-controlled energy homeostasis. Cell. 2025 Jun 26;188(13):3550-3566.e22. doi: 10.1016/j.cell.2025.04.001. Epub 2025 Apr 23.

  67. Puente-Ruiz SC, Ide L, Schuller J, Ben-Kraiem A, Hoffmann A, Ghosh A, Noé F, Wolfrum C, Krause K, Gericke M, Klöting N, Brüning JC, Wunderlich FT, Blüher M, Jais A. (2025) B cell-derived nociceptin/orphanin FQ contributes to impaired glucose tolerance and insulin resistance in obesity. iScience. 2025 Jun 4;28(7):112819. doi: 10.1016/j.isci.2025.112819. eCollection 2025 Jul 18.

  68. Kaul H, Isermann L, Senft K, Popovic M, Georgomanolis T, Baumann L, Sivanesan P, Pouikli A, Nolte H, Lucic B, Hildebrandt X, Seidel K, Gnad T, Gaedke F, Göbel U, Peters F, Cherevatenko M, Park JH, Schauss A, Peltzer N, Brüning JC, Kornfeld JW, Pfeifer A, Langer T, Lusic M, Wickström SA, Frezza C, Trifunovic A. (2025) 2-hydroxyglutarate mediates whitening of brown adipocytes coupled to nuclear softening upon mitochondrial dysfunction. Nat Metab. 2025 Aug;7(8):1593-1613. doi: 10.1038/s42255-025-01332-8. Epub 2025 Aug 1.

Prof. Eitan Okun
Prof. Eitan Okun

Prof. Eitan Okun

Aging of the Brain

  1. Illouz T, Madar R, Biragyn A, Okun E. (2019) Restoring microglial and astroglial homeostasis using DNA immunization in a Down Syndrome mouse model. Brain Behav Immun. 2019 Jan;75:163-180. doi: 10.1016/j.bbi.2018.10.004. Epub 2018 Oct 25.

  2. Lev-Vachnish Y, Cadury S, Rotter-Maskowitz A, Feldman N, Roichman A, Illouz T, Varvak A, Nicola R, Madar R, Okun E. (2019) L-Lactate Promotes Adult Hippocampal Neurogenesis. Front Neurosci. 2019 May 24;13:403. doi: 10.3389/fnins.2019.00403. eCollection 2019.

  3. Illouz T, Madar R, Okun E. (2020) A modified Barnes maze for an accurate assessment of spatial learning in mice. J Neurosci Methods. 2020 Mar 15;334:108579. doi: 10.1016/j.jneumeth.2020.108579.

  4. Moshe H., Gersner R., Okun E., Barnea-Ygael N., Zangen A., Sredni B. (2020) A Tellurium-Based Small Immunomodulatory Molecule Ameliorates Depression-Like Behavior in Two Distinct Rat Models. Neuromolecular Med. 2020 Sep;22(3):437-446. doi: 10.1007/s12017-020-08603-5.

  5. Nicola R, Okun E. (2020) Food and Age: It Takes Two to Degenerate. Front Aging Neurosci. 2020 Jun 26;12:182. doi: 10.3389/fnagi.2020.00182. eCollection 2020.

  6. Ben-Zeev T, Hirsh T, Weiss I, Gornstein M, Okun E. (2020) The Effects of High-intensity Functional Training (HIFT) on Spatial Learning, Visual Pattern Separation and Attention Span in Adolescents. Front Behav Neurosci. 2020 Sep 14;14:577390. doi: 10.3389/fnbeh.2020.577390. eCollection 2020.

  7. Ben-Zeev T, Weiss I, Ashri S, Heled Y, Ketko I, Yanovich R, Okun E. (2020) Mild Physical Activity Does Not Improve Spatial Learning in a Virtual Environment. Front Behav Neurosci. 2020 Nov 17;14:584052. doi: 10.3389/fnbeh.2020.584052. eCollection 2020.

  8. Ben-Zeev T, Okun E. (2021) High-Intensity Functional Training: Molecular Mechanisms and Benefits. Neuromolecular Med. 2021 Sep;23(3):335-338. doi: 10.1007/s12017-020-08638-8.

  9. Illouz T, Biragyn A, Frenkel-Morgenstern M, Weissberg O, Gorohovski A, Merzon E, Green I, Iulita F, Flores-Aguilar L, Dierssen M, De Toma I, Lifshitz H, Antonarakis SE, Yu E, Herault Y, Potier MC, Botté A, Roper R, Sredni B, Sarid R, London J, Mobley W, Strydom A, Okun E. (2021) Specific Susceptibility to COVID-19 in Adults with Down Syndrome. Neuromolecular Med. 2021 Dec;23(4):561-571. doi: 10.1007/s12017-021-08651-5.

  10. Illouz T, Nicola R, Ben-Shushan L, Madar R, Biragyn A, Okun E. (2021) Maternal antibodies facilitate Amyloid-β clearance by activating Fc-receptor-Syk-mediated phagocytosis. Commun Biol. 2021 Mar 12;4(1):329. doi: 10.1038/s42003-021-01851-6.

  11. Kim K, Wang X, Ragonnaud E, Bodogai M, Illouz T, DeLuca M, McDevitt RA, Gusev F, Okun E, Rogaev E, Biragyn A. (2021) Therapeutic B-cell depletion reverses progression of Alzheimer's disease. Nat Commun. 2021 Apr 12;12(1):2185. doi: 10.1038/s41467-021-22479-4.

  12. Nicola R, Okun E. (2021) Adult Hippocampal Neurogenesis: One Lactate to Rule Them All. Neuromolecular Med. 2021 Dec;23(4):445-448. doi: 10.1007/s12017-021-08658-y.

  13. Illouz T, Biragyn A, Frenkel-Morgenstern M, Weissberg O, Gorohovski A, Merzon E, Green I, Iulita F, Flores-Aguilar L, Dierssen M, De Toma I, Lifshitz H, Antonarakis SE, Yu E, Herault Y, Potier MC, Botté A, Roper R, Sredni B, Sarid R, London J, Mobley W, Strydom A, Okun E. (2021) Correction to: Specific Susceptibility to COVID-19 in Adults with Down Syndrome. Neuromolecular Med. 2021 Dec;23(4):572-573. doi: 10.1007/s12017-021-08657-z.

  14. Illouz T, Biragyn A, Iulita MF, Flores-Aguilar L, Dierssen M, De Toma I, Antonarakis SE, Yu E, Herault Y, Potier MC, Botté A, Roper R, Sredni B, London J, Mobley W, Strydom A, Okun E. (2021) Immune Dysregulation and the Increased Risk of Complications and Mortality Following Respiratory Tract Infections in Adults With Down Syndrome. Front Immunol. 2021 Jun 25;12:621440. doi: 10.3389/fimmu.2021.621440. eCollection 2021.

  15. Illouz T, Madar R, Hirsh T, Biragyn A, Okun E. (2021) Induction of an effective anti-Amyloid-β humoral response in aged mice. Vaccine. 2021 Aug 9;39(34):4817-4829. doi: 10.1016/j.vaccine.2021.07.023.

  16. Cho Y, Bae HG, Okun E, Arumugam TV, Jo DG. (2022) Physiology and pharmacology of amyloid precursor protein. Pharmacol Ther. 2022 Jul;235:108122. doi: 10.1016/j.pharmthera.2022.108122.

  17. Ng GY, Sheng DPLK, Bae HG, Kang SW, Fann DY, Park J, Kim J, Alli-Shaik A, Lee J, Kim E, Park S, Han JW, Karamyan V, Okun E, Dheen T, Hande MP, Vemuganti R, Mallilankaraman K, Lim LHK, Kennedy BK, Drummond GR, Sobey CG, Gunaratne J, Mattson MP, Foo RS, Jo DG, Arumugam TV. Integrative epigenomic and transcriptomic analyses reveal metabolic switching by intermittent fasting in brain. Geroscience. 2022 Aug;44(4):2171-2194. doi: 10.1007/s11357-022-00537-z.

  18. Nicola R, Madar R, Okun E. (2022) HCAR1-Mediated L-Lactate Signaling Suppresses Microglial Phagocytosis. Neuromolecular Med. 2022 Dec;24(4):399-404. doi: 10.1007/s12017-022-08710-5.

  19. Hüls A, Feany PT, Zisman SI, Costa ACS, Dierssen M, Balogh R, Bargagna S, Baumer NT, Brandão AC, Carfi A, Chicoine BA, Ghosh S, Lakhanpaul M, Levin J, Lunsky Y, Manso C, Okun E, Real de Asua D, Rebillat AS, Rohrer TR, Sgandurra G, Valentini D, Sherman SL, Strydom A, On Behalf Of The Trisomy Research Society Covid-Initiative. (2022) COVID-19 Vaccination of Individuals with Down Syndrome-Data from the Trisomy 21 Research Society Survey on Safety, Efficacy, and Factors Associated with the Decision to Be Vaccinated. Vaccines (Basel). 2022 Mar 29;10(4):530. doi: 10.3390/vaccines10040530.

  20. Samuel I, Ben-Haroush Schyr R, Arad Y, Attali T, Azulai S, Bergel M, Halfon A, Hefetz L, Hirsch T, Israeli H, Lax N, Nitzan K, Sender D, Sweetat S, Okun E, Rosenmann H, Ben-Zvi D. (2022) Sleeve Gastrectomy Reduces Glycemia but Does Not Affect Cognitive Impairment in Lean 5xFAD Mice. Front Neurosci. 2022 Aug 11;16:937663. doi: 10.3389/fnins.2022.937663. eCollection 2022.

  21. Habashi M, Vutla S, Tripathi K, Senapati S, Chauhan PS, Haviv-Chesner A, Richman M, Mohand SA, Dumulon-Perreault V, Mulamreddy R, Okun E, Chill JH, Guérin B, Lubell WD, Rahimipour S. (2022) Early diagnosis and treatment of Alzheimer's disease by targeting toxic soluble Aβ oligomers. Proc Natl Acad Sci U S A. 2022 Dec 6;119(49):e2210766119. doi: 10.1073/pnas.2210766119.

  22. Ben-Ami L, Ravona-Springer R, Tsarfaty G, Raizman R, Shumacher A, Sharvit-Ginon I, Greenbaum L, Bendlin BB, Okun E, Heymann A, Schnaider Beeri M, Livny A. (2023) Neural correlates of subjective cognitive decline in adults at high risk for Alzheimer's disease. Front Aging Neurosci. 2023 Feb 1;15:1067196. doi: 10.3389/fnagi.2023.1067196. eCollection 2023.

  23. Bar E, Fischer I, Rokach M, Elad-Sfadia G, Shirenova S, Ophir O, Trangle SS, Okun E, Barak B. (2023) Neuronal deletion of Gtf2i results in developmental microglial alterations in a mouse model related to Williams syndrome. Glia. 2024 Jun;72(6):1117-1135. doi: 10.1002/glia.24519. Epub 2024 Mar 7.

  24. Illouz T, Ascher LAB, Madar R, Okun E. (2024) Unbiased analysis of spatial learning strategies in a modified Barnes maze using convolutional neural networks. Sci Rep. 2024 Jul 10;14(1):15944. doi: 10.1038/s41598-024-66855-8.

  25. Wang X, Campbell B, Bodogai M, McDevitt RA, Patrikeev A, Gusev F, Ragonnaud E, Kumaraswami K, Shirenova S, Vardy K, Alameh MG, Weissman D, Ishikawa-Ankerhold H, Okun E, Rogaev E, Biragyn A. (2024) CD8+ T cells exacerbate AD-like symptoms in mouse model of amyloidosis. Brain Behav Immun. 2024 Nov;122:444-455. doi: 10.1016/j.bbi.2024.08.045. Epub 2024 Aug 25.

  26. Fruitman Davidi A, Shirenova S, Michaelovich D, Benedetti G, Shtrasberg H, Shoval I, Hauschner H, Oz G, Vardy K, Hirsh T, Madar R, Stern EA, Rosenmann H, Biragyn A, Okun E. (2025) Dural ectopic lymphatic structures accumulate during aging and exhibit dysregulation in neurodegenerative diseases. Proc Natl Acad Sci U S A. 2025 Aug 19;122(33):e2425081122. doi: 10.1073/pnas.2425081122. Epub 2025 Aug 12.

Prof. Dr. Andreas Beyer
Prof. Dr. Andreas Beyer

Prof. Dr. Andreas Beyer

Systems Biology of Aging

  1. Späth MR, Bartram MP, Palacio-Escat N, Hoyer KJR, Debes C, Demir F, Schroeter CB, Mandel AM, Grundmann F, Ciarimboli G, Beyer A, Kizhakkedathu JN, Brodesser S, Göbel H, Becker JU, Benzing T, Schermer B, Höhne M, Burst V, Saez-Rodriguez J, Huesgen PF, Müller RU, Rinschen MM. (2019) The proteome microenvironment determines the protective effect of preconditioning in cisplatin-induced acute kidney injury. Kidney Int. 2019 Feb;95(2):333-349. doi: 10.1016/j.kint.2018.08.037. Epub 2018 Dec 3.

  2. Shao W, Guo T, Toussaint NC, Xue P, Wagner U, Li L, Charmpi K, Zhu Y, Wu J, Buljan M, Sun R, Rutishauser D, Hermanns T, Fankhauser CD, Poyet C, Ljubicic J, Rupp N, Rüschoff JH, Zhong Q, Beyer A, Ji J, Collins BC, Liu Y, Rätsch G, Wild PJ, Aebersold R. (2019) Comparative analysis of mRNA and protein degradation in prostate tissues indicates high stability of proteins. Nat Commun. 2019 Jun 7;10(1):2524. doi: 10.1038/s41467-019-10513-5.

  3. Lapin D, Kovacova V, Sun X, Dongus JA, Bhandari D, von Born P, Bautor J, Guarneri N, Rzemieniewski J, Stuttmann J, Beyer A, Parker JE. (2019) A Coevolved EDS1-SAG101-NRG1 Module Mediates Cell Death Signaling by TIR-Domain Immune Receptors. Plant Cell. 2019 Oct;31(10):2430-2455. doi: 10.1105/tpc.19.00118. Epub 2019 Jul 16.

  4. Soste M, Charmpi K, Lampert F, Gerez JA, van Oostrum M, Malinovska L, Boersema PJ, Prymaczok NC, Riek R, Peter M, Vanni S, Beyer A, Picotti P. (2019) Proteomics-Based Monitoring of Pathway Activity Reveals that Blocking Diacylglycerol Biosynthesis Rescues from Alpha-Synuclein Toxicity. Cell Syst. 2019 Sep 25;9(3):309-320.e8. doi: 10.1016/j.cels.2019.07.010. Epub 2019 Sep 11.

  5. Hahn O, Drews LF, Nguyen A, Tatsuta T, Gkioni L, Hendrich O, Zhang Q, Langer T, Pletcher S, Wakelam MJO, Beyer A, Grönke S, Partridge L. (2019) A nutritional memory effect counteracts benefits of dietary restriction in old mice. Nat Metab. 2019 Nov;1(11):1059-1073. doi: 10.1038/s42255-019-0121-0. Epub 2019 Oct 21.

  6. Johnsen M, Kubacki T, Yeroslaviz A, Späth MR, Mörsdorf J, Göbel H, Bohl K, Ignarski M, Meharg C, Habermann B, Altmüller J, Beyer A, Benzing T, Schermer B, Burst V, Müller RU. (2020) The Integrated RNA Landscape of Renal Preconditioning against Ischemia-Reperfusion Injury. J Am Soc Nephrol. 2020 Apr;31(4):716-730. doi: 10.1681/ASN.2019050534. Epub 2020 Feb 28.

  7. Kamrad S, Grossbach J, Rodríguez-López M, Mülleder M, Townsend S, Cappelletti V, Stojanovski G, Correia-Melo C, Picotti P, Beyer A, Ralser M, Bähler J. (2020) Pyruvate kinase variant of fission yeast tunes carbon metabolism, cell regulation, growth and stress resistance. Mol Syst Biol. 2020 Apr;16(4):e9270. doi: 10.15252/msb.20199270.

  8. Charmpi K, Guo T, Zhong Q, Wagner U, Sun R, Toussaint NC, Fritz CE, Yuan C, Chen H, Rupp NJ, Christiansen A, Rutishauser D, Rüschoff JH, Fankhauser C, Saba K, Poyet C, Hermanns T, Oehl K, Moore AL, Beisel C, Calzone L, Martignetti L, Zhang Q, Zhu Y, Martínez MR, Manica M, Haffner MC, Aebersold R, Wild PJ, Beyer A. (2020) Convergent network effects along the axis of gene expression during prostate cancer progression. Genome Biol. 2020 Dec 14;21(1):302. doi: 10.1186/s13059-020-02188-9.

  9. Cappelletti V, Hauser T, Piazza I, Pepelnjak M, Malinovska L, Fuhrer T, Li Y, Dörig C, Boersema P, Gillet L, Grossbach J, Dugourd A, Saez-Rodriguez J, Beyer A, Zamboni N, Caflisch A, de Souza N, Picotti P. (2021) Dynamic 3D proteomes reveal protein functional alterations at high resolution in situ. Cell. 2021 Jan 21;184(2):545-559.e22. doi: 10.1016/j.cell.2020.12.021. Epub 2020 Dec 23.

  10. Lackner A, Sehlke R, Garmhausen M, Giuseppe Stirparo G, Huth M, Titz-Teixeira F, van der Lelij P, Ramesmayer J, Thomas HF, Ralser M, Santini L, Galimberti E, Sarov M, Stewart AF, Smith A, Beyer A, Leeb M. (2021) Cooperative genetic networks drive embryonic stem cell transition from naïve to formative pluripotency. EMBO J. 2021 Apr 15;40(8):e105776. doi: 10.15252/embj.2020105776. Epub 2021 Mar 9.

  11. Tain LS, Sehlke R, Meilenbrock RL, Leech T, Paulitz J, Chokkalingam M, Nagaraj N, Grönke S, Fröhlich J, Atanassov I, Mann M, Beyer A, Partridge L. (2021) Tissue-specific modulation of gene expression in response to lowered insulin signalling in Drosophila. Elife. 2021 Apr 21;10:e67275. doi: 10.7554/eLife.67275.

  12. Tognetti M, Gabor A, Yang M, Cappelletti V, Windhager J, Rueda OM, Charmpi K, Esmaeilishirazifard E, Bruna A, de Souza N, Caldas C, Beyer A, Picotti P, Saez-Rodriguez J, Bodenmiller B. (2021) Deciphering the signaling network of breast cancer improves drug sensitivity prediction. Cell Syst. 2021 May 19;12(5):401-418.e12. doi: 10.1016/j.cels.2021.04.002. Epub 2021 Apr 30.

  13. Santini L, Halbritter F, Titz-Teixeira F, Suzuki T, Asami M, Ma X, Ramesmayer J, Lackner A, Warr N, Pauler F, Hippenmeyer S, Laue E, Farlik M, Bock C, Beyer A, Perry ACF, Leeb M. (2021) Genomic imprinting in mouse blastocysts is predominantly associated with H3K27me3. Nat Commun. 2021 Jun 21;12(1):3804. doi: 10.1038/s41467-021-23510-4.

  14. Charmpi K, Chokkalingam M, Johnen R, Beyer A. (2021) Optimizing network propagation for multi-omics data integration. PLoS Comput Biol. 2021 Nov 11;17(11):e1009161. doi: 10.1371/journal.pcbi.1009161. eCollection 2021 Nov.

  15. Leote AC, Wu X, Beyer A. (2022) Regulatory network-based imputation of dropouts in single-cell RNA sequencing data. PLoS Comput Biol. 2022 Feb 17;18(2):e1009849. doi: 10.1371/journal.pcbi.1009849. eCollection 2022 Feb.

  16. Huth M, Santini L, Galimberti E, Ramesmayer J, Titz-Teixeira F, Sehlke R, Oberhuemer M, Stummer S, Herzog V, Garmhausen M, Romeike M, Chugunova A, Leesch F, Holcik L, Weipoltshammer K, Lackner A, Schoefer C, von Haeseler A, Buecker C, Pauli A, Ameres SL, Smith A, Beyer A, Leeb M. (2022) NMD is required for timely cell fate transitions by fine-tuning gene expression and regulating translation. Genes Dev. 2022 Mar 1;36(5-6):348-367. doi: 10.1101/gad.347690.120. Epub 2022 Mar 3.

  17. Fraser HC, Kuan V, Johnen R, Zwierzyna M, Hingorani AD, Beyer A, Partridge L. (2022) Biological mechanisms of aging predict age-related disease co-occurrence in patients. Aging Cell. 2022 Apr;21(4):e13524. doi: 10.1111/acel.13524. Epub 2022 Mar 8.

  18. Dewald F, Suárez I, Johnen R, Grossbach J, Moran-Tovar R, Steger G, Joachim A, Rubio GH, Fries M, Behr F, Kley J, Lingnau A, Kretschmer A, Gude C, Baeza-Flores G, Del Valle DL, Roblero-Hernandez A, Magana-Cerino J, Hernandez AT, Ruiz-Quinones J, Schega K, Linne V, Junker L, Wunsch M, Heger E, Knops E, Di Cristanziano V, Meyer M, Hünseler C, Weber LT, Lüers JC, Quade G, Wisplinghoff H, Tiemann C, Zotz R, Jomaa H, Pranada A, Herzum I, Cullen P, Schmitz FJ, Philipsen P, Kirchner G, Knabbe C, Hellmich M, Buess M, Wolff A, Kossow A, Niessen J, Jeworutzki S, Schräpler JP, Lässig M, Dötsch J, Fätkenheuer G, Kaiser R, Beyer A, Rybniker J, Klein F. (2022) Effective high-throughput RT-qPCR screening for SARS-CoV-2 infections in children. Nat Commun. 2022 Jun 25;13(1):3640. doi: 10.1038/s41467-022-30664-2.

  19. Mackmull MT, Nagel L, Sesterhenn F, Muntel J, Grossbach J, Stalder P, Bruderer R, Reiter L, van de Berg WDJ, de Souza N, Beyer A, Picotti P. (2022) Global, in situ analysis of the structural proteome in individuals with Parkinson's disease to identify a new class of biomarker. Nat Struct Mol Biol. 2022 Oct;29(10):978-989. doi: 10.1038/s41594-022-00837-0. Epub 2022 Oct 12.

  20. Steuernagel L, Lam BYH, Klemm P, Dowsett GKC, Bauder CA, Tadross JA, Hitschfeld TS, Del Rio Martin A, Chen W, de Solis AJ, Fenselau H, Davidsen P, Cimino I, Kohnke SN, Rimmington D, Coll AP, Beyer A, Yeo GSH, Brüning JC. (2022) HypoMap-a unified single-cell gene expression atlas of the murine hypothalamus. Nat Metab. 2022 Oct;4(10):1402-1419. doi: 10.1038/s42255-022-00657-y. Epub 2022 Oct 20.

  21. Debès C, Papadakis A, Grönke S, Karalay Ö, Tain LS, Mizi A, Nakamura S, Hahn O, Weigelt C, Josipovic N, Zirkel A, Brusius I, Sofiadis K, Lamprousi M, Lu YX, Huang W, Esmaillie R, Kubacki T, Späth MR, Schermer B, Benzing T, Müller RU, Antebi A, Partridge L, Papantonis A, Beyer A. (2023) Ageing-associated changes in transcriptional elongation influence longevity. Nature. 2023 Apr;616(7958):814-821. doi: 10.1038/s41586-023-05922-y. Epub 2023 Apr 12.

  22. Kruglyak L, Beyer A, Bloom JS, Grossbach J, Lieberman TD, Mancuso CP, Rich MS, Sherlock G, Kaplan CD. (2023) Insufficient evidence for non-neutrality of synonymous mutations. Nature. 2023 Apr;616(7957):E8-E9. doi: 10.1038/s41586-023-05865-4. Epub 2023 Apr 19.

  23. Monzó C, Gkioni L, Beyer A, Valenzano DR, Grönke S, Partridge L. (2023) Dietary restriction mitigates the age-associated decline in mouse B cell receptor repertoire diversity. Cell Rep. 2023 Jul 25;42(7):112722. doi: 10.1016/j.celrep.2023.112722. Epub 2023 Jun 28.

  24. Llamas E, Koyuncu S, Lee HJ, Wehrmann M, Gutierrez-Garcia R, Dunken N, Charura N, Torres-Montilla S, Schlimgen E, Mandel AM, Theile EB, Grossbach J, Wagle P, Lackmann JW, Schermer B, Benzing T, Beyer A, Pulido P, Rodriguez-Concepcion M, Zuccaro A, Vilchez D. (2023) In planta expression of human polyQ-expanded huntingtin fragment reveals mechanisms to prevent disease-related protein aggregation. Nat Aging. 2023 Nov;3(11):1345-1357. doi: 10.1038/s43587-023-00502-1. Epub 2023 Oct 2.

  25. Papadakis A, Gyenis A, Pothof J, H J Hoeijmakers J, Papantonis A, Beyer A. (2023) Age-associated transcriptional stress due to accelerated elongation and increased stalling of RNAPII. Nat Genet. 2023 Dec;55(12):2011-2012. doi: 10.1038/s41588-023-01601-w.

  26. Zhong Q, Sun R, Aref AT, Noor Z, Anees A, Zhu Y, Lucas N, Poulos RC, Lyu M, Zhu T, Chen GB, Wang Y, Ding X, Rutishauser D, Rupp NJ, Rueschoff JH, Poyet C, Hermanns T, Fankhauser C, Rodríguez Martínez M, Shao W, Buljan M, Neumann JF, Beyer A, Hains PG, Reddel RR, Robinson PJ, Aebersold R, Guo T, Wild PJ. (2023) Proteomic-based stratification of intermediate-risk prostate cancer patients. Life Sci Alliance. 2023 Dec 4;7(2):e202302146. doi: 10.26508/lsa.202302146. Print 2024 Feb.

  27. Palikyras S, Sofiadis K, Stavropoulou A, Danieli-Mackay A, Varamogianni-Mamatsi V, Hörl D, Nasiscionyte S, Zhu Y, Papadionysiou I, Papadakis A, Josipovic N, Zirkel A, O'Connell A, Loughran G, Keane J, Michel A, Wagner W, Beyer A, Harz H, Leonhardt H, Lukinavicius G, Nikolaou C, Papantonis A. (2024) Rapid and synchronous chemical induction of replicative-like senescence via a small molecule inhibitor. Aging Cell. 2024 Apr;23(4):e14083. doi: 10.1111/acel.14083. Epub 2024 Jan 9.

  28. Unger Avila P, Padvitski T, Leote AC, Chen H, Saez-Rodriguez J, Kann M, Beyer A. (2024) Gene regulatory networks in disease and ageing. Nat Rev Nephrol. 2024 Sep;20(9):616-633. doi: 10.1038/s41581-024-00849-7. Epub 2024 Jun 12.

  29. Leote AC, Lopes F, Beyer A. (2024) Loss of coordination between basic cellular processes in human aging. Nat Aging. 2024 Oct;4(10):1432-1445. doi: 10.1038/s43587-024-00696-y. Epub 2024 Sep 3.

  30. Papantonis A, Antebi A, Partridge L, Beyer A. (2025) Age-associated changes in transcriptional elongation and their effects on homeostasis. Trends Cell Biol. 2025 Aug;35(8):645-650. doi: 10.1016/j.tcb.2024.11.005. Epub 2024 Dec 19.

  31. Nagel L, Grossbach J, Cappelletti V, Dörig C, Picotti P, Beyer A. (2025) Analysis of Limited Proteolysis-Coupled Mass Spectrometry Data. Mol Cell Proteomics. 2025 Apr;24(4):100934. doi: 10.1016/j.mcpro.2025.100934. Epub 2025 Mar 7.

  32. Gkioni L, Nespital T, Baghdadi M, Monzó C, Bali J, Nassr T, Cremer AL, Beyer A, Deelen J, Backes H, Grönke S, Partridge L. (2025) The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan. Nat Aging. 2025 Jul;5(7):1249-1265. doi: 10.1038/s43587-025-00876-4. Epub 2025 May 28.

  33. Ayata P, Crowley JM, Challman MF, Sahasrabuddhe V, Gratuze M, Werneburg S, Ribeiro D, Hays EC, Durán-Laforet V, Faust TE, Hwang P, Mendes Lopes F, Nikopoulou C, Buchholz S, Murphy RE, Mei T, Pimenova AA, Romero-Molina C, Garretti F, Patel TA, De Sanctis C, Ramirez Jimenez AV, Crow M, Weiss FD, Ulrich JD, Marcora E, Murray JW, Meissner F, Beyer A, Hasson D, Crary JF, Schafer DP, Holtzman DM, Goate AM, Tarakhovsky A, Schaefer A. (2025) Lymphoid gene expression supports neuroprotective microglia function. Nature. 2025 Dec;648(8092):157-165. doi: 10.1038/s41586-025-09662-z. Epub 2025 Nov 5.

Dr. Moran Dvela - Levitt

Dr. Moran Dvela - Levitt

Aging and Proteostasis

Dr. Moran Dvela - Levitt

  1. Dvela-Levitt M., Maria Kost-Alimova, Maheswarareddy Emani, Eva Kohnert, Rebecca Thompson, Eriene-Heidi Sidhom, Ana Rivadeneira, Nareh Sahakian, Julie Roignot, Gregory Papagregoriou, Monica S Montesinos, Abbe R Clark, David McKinney, Juan Gutierrez, Mark Roth, Lucienne Ronco, Esther Elonga, Todd A Carter, Andreas Gnirke, Michelle Melanson, Kate Hartland, Nicolas Wieder, Jane C-H Hsu, Constantinos Deltas, Rebecca Hughey, Anthony J Bleyer, Stanislav Kmoch, Martina Živná, Veronika Barešova, Savithri Kota, Johannes Schlondorff, Myriam Heiman, Seth L Alper, Florence Wagner, Astrid Weins, Todd R Golub, Eric S Lander, Anna Greka (2019) Small Molecule Targets TMED9 and Promotes Lysosomal Degradation to Reverse Proteinopathy, Cell 2019 Jul 25;178(3):521-535.e23.  doi: 10.1016/j.cell.2019.07.002.

  2. Kost-Alimova M, Sidhom EH, Satyam A, Chamberlain BT, Dvela-Levitt M, Melanson M, Alper SL, Santos J, Gutierrez J, Subramanian A, Byrne PJ, Grinkevich E, Reyes-Bricio E, Kim C, Clark AR, Watts AJB, Thompson R, Marshall J, Pablo JL, Coraor J, Roignot J, Vernon KA, Keller K, Campbell A, Emani M, Racette M, Bazua-Valenti S, Padovano V, Weins A, McAdoo SP, Tam FWK, Ronco L, Wagner F, Tsokos GC, Shaw JL, Greka A. (2020) A High-Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung Injury. Cell Rep Med 1(8):100137. doi: 10.1016/j.xcrm.2020.100137.

  3. Dvela-Levitt M, Shaw JL, Greka A. (2021) A Rare Kidney Disease To Cure Them All? Towards Mechanism-Based Therapies for Proteinopathies. Trends Mol Med. 27(4):394-409. doi: 10.1016/j.molmed.

  4. Wieder N, Fried JC, Kim C, Sidhom EH, Brown MR, Marshall JL, Arevalo C, Dvela-Levitt M, Kost-Alimova M, Sieber J, Gabriel KR, Pacheco J, Clish C, Abbasi HS, Singh S, Rutter JC, Therrien M, Yoon H, Lai ZW, Baublis A, Subramanian R, Devkota R, Small J, Sreekanth V, Han M, Lim D, Carpenter AE, Flannick J, Finucane H, Haigis MC, Claussnitzer M, Sheu E, Stevens B, Wagner BK, Choudhary A, Shaw JL, Pablo JL, Greka A. (2023) FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity. Cell Metab. 35(5):887-905.e11. doi: 10.1016/j.cmet.

  5. Horesh N, Pelov I, Pogodin I, Zannadeh H, Rosen H, Mikhrina AL, Dvela-Levitt M, Sampath VP, Lichtstein D. (2024) Involvement of the Na+, K+-ATPase α1 Isoform and Endogenous Cardiac Steroids in Depression- and Manic-like Behaviors. Int J Mol Sci. 25(3):1644. doi: 10.3390/ijms25031644.

  6. Bazua-Valenti S, Brown MR, Zavras J, Riedl Khursigara M, Grinkevich E, Sidhom EH, Keller KH, Racette M, Dvela-Levitt M, Quintanova C, Demirci H, Sewerin S, Goss AC, Lin J, Yoo H, Vaca Jacome AS, Papanastasiou M, Udeshi N, Carr SA, Himmerkus N, Bleich M, Mutig K, Bachmann S, Halbritter J, Kmoch S, Živná M, Kidd K, Bleyer AJ, Weins A, Alper SL, Shaw JL, Kost-Alimova M, Pablo JLB, Greka A. (2024) Disrupted uromodulin trafficking is rescued by targeting TMED cargo receptors. J Clin Invest. 134(24):e180347. doi: 10.1172/JCI180347.

  7. Živná M, Dostálová G, Barešová V, Mušálková D, Svojšová K, Meiseles D, Kinstlinger S, Kuchař L, Asfaw B, Poupětová H, Vlášková H, Kmochová T, Vyleťal P, Hartmannová H, Hodaňová K, Stránecký V, Steiner-Mrázová L, Hnízda A, Živný J, Radina M, Votruba M, Sovová J, Trešlová H, Stolnaja L, Reková P, Roblová L, Honsová E, Rychlík I, Dvela-Levitt M, Bleyer AJ, Linhart A, Sikora J, Kmoch S. (2025) Misprocessing of α -Galactosidase A, Endoplasmic Reticulum Stress, and the Unfolded Protein Response. J Am Soc Nephrol. 36(4):628-644. doi: 10.1681/ASN.0000000535.

  8. Kinstlinger S, Dvela-Levitt M. (2025) Opening New Routes for Kidney Therapy. J Am Soc Nephrol. 36(3):519-521. doi: 10.1681/ASN.0000000616.

  9. Meiseles D, Arbeli N, Dvela-Levitt M. (2025) When Proteins Go Berserk: The Unfolded Protein Response and ER Stress. Nephron. 149(10):609-619. doi: 10.1159/000544971.

  10. Daoud Sarsour A, Kinstlinger S, Nizar R, Amos N, Arbeli N, Kazimirsky G, Bronshtein-Berger I, Fried I, Unger R, Brodie C, Dvela-Levitt M. (2025) Targeting the Cargo Receptor TMED9 as a Therapeutic Strategy Against Brain Tumors. Cells. 14(11):772. doi: 10.3390/cells14110772.

  11. Kmoch S, Živná M, Dvela-Levitt M, Braun F, Rozenfeld P, Wanner C, Hughes D, Schiffmann R, Warnock DG. Expanded View of the Pathophysiology of Fabry Disease. Nephron. 149(10):620-624. doi: 10.1159/000546555.

Dr. Stephanie Panier

Dr. Stephanie Panier

Aging and DNA repair

Dr. Stephanie Panier

  1. Panier S., Marija Maric, Graeme Hewitt, Emily Mason-Osann, Himabindu Gali, Anqi Dai, Adam Labadorf, Jean-Hugues Guervilly, Philip Ruis, Sandra Segura-Bayona, Ondrej Belan, Paulina Marzec, Pierre-Henri L Gaillard, Rachel L Flynn, Simon J Boulton (2019) SLX4IP Antagonizes Promiscuous BLM Activity during ALT Maintenance, Moll Cell. 2019 Oct 3;76(1):27-43.e11. doi: 10.1016/j.molcel.2019.07.010. Epub 2019 Aug 22.

  2. Klaric JA, Wüst S, Panier S. (2021) New Faces of old Friends: Emerging new Roles of RNA-Binding Proteins in the DNA Double-Strand Break Response. Front Mol Biosci. 2021 May 7;8:668821. doi: 10.3389/fmolb.2021.668821. eCollection 2021.

  3. Panier S. (2023) Cancer cells remodel nuclear actin filaments to resist chemotherapy. Nature. 2023 Apr;616(7955):40-42. doi: 10.1038/d41586-023-00801-y.

  4. Wagener R, Brandes D, Jung M, Huetzen MA, Bergmann AK, Panier S, Picard D, Fischer U, Jachimowicz RD, Borkhardt A, Brozou T. (2024) Optical genome mapping identifies structural variants in potentially new cancer predisposition candidate genes in pediatric cancer patients. Int J Cancer. 2024 Feb 15;154(4):607-614. doi: 10.1002/ijc.34721. Epub 2023 Sep 30.

  5. Panier S, Wang S, Schumacher B. (2024) Genome Instability and DNA Repair in Somatic and Reproductive Aging. Annu Rev Pathol. 2024 Jan 24;19:261-290. doi: 10.1146/annurev-pathmechdis-051122-093128. Epub 2023 Oct 13.

  6. Ratz L, Baek S, Panier S. (2025) Revisiting Genomic Instability, Tumor Microenvironment and Immune Response in High-Grade Serous Ovarian Cancer. Geburtshilfe Frauenheilkd. 2025 Jun 11;85(7):694-709. doi: 10.1055/a-2613-0489. eCollection 2025 Jul.

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